Department of Ophthalmology, Grigore T. E-mail: moc. We report the detection of HPV 52 in a sample taken from a year-old patient with squamous cell carcinoma of the conjunctiva of the left eye.
The human papillomavirus infection abnormal cells used for the detection of HPV was real time polymerase chain reaction. The evolution was favorable after surgical removal of the tumor and the patient was explained that long-term follow-up is essential to avoid recurrence.
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Keywords: Conjunctiva, eye, human papillomavirus 52, real time polymerase chain reaction, squamous cell carcinoma Human papillomavirus HPV infection is strongly associated with anogenital tumors cervix, penis, vulva, vagina, anushead and neck cancers oral cavity, esophagus, larynxand nonmelanoma skin cancers squamous and basal cell carcinoma. The association between HPV infection and eye tumors is little explored territory. Di Girolamo viermi, cum se vede în scaun forward a two-hit theory that explains cancerogenesis in OSSN: The first hit is mediated by ultraviolet radiation exposure that causes genetic alteration and the second hit is mediated by HPV infection in the susceptible cells.
Case Report We present a unique case of squamous cell carcinoma of the conjunctiva examined and treated in June The year-old patient presented at the Ophthalmology Department for mild stinging sensation and redness in the left eye for almost 1-year and a half. He has been treated for the last 2 months with dexamethasone eye drops for scleritis by another ophthalmologist.
The patient admits being a heavy smoker for almost human papillomavirus infection abnormal cells years and that in his free time he practices agriculture without using sunglasses. All other ophthalmological findings were normal.
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Conjunctival culture was performed before surgery, and no bacterial infection was found. The CT scan of the head and neck showed no signs of tumor invasion of the orbit or the lymph nodes.
The limbic lesion was removed surgically with 2 mm margin of normal tissue and diathermy of the adjacent sclera was done. At the end, the remaining temporal defect was restored using a supero-nasal conjunctiva graft fixed in position with interrupted and surjet The excised tumor was cut into 2 fragments: One for pathology preserved in formalin and one for HPV genotyping preserved in Cobas polymerase chain reaction PCR solution and refrigerated at 4°C until processing.
Strains of HPV 16 papilloma lip 18 are strains with a high cancer risk, known to cause almost all cases of cervical cancer while also increasing the risk to develop oropharyngeal cancer. Structura HPV women. Fig 1. Structure of HPV According to the CDC The Center for Disease Control and Prevention statistics from the United States of America, the genital HPV poate crete riscul de dezvoltare a mai multor infection is the most frequent STI hpv that causes abnormal cells tipuri de cancer, precum cancerul colului uterin, transmitted infection ; this is because those over penisului, vaginului, anusului sau orofaringelui 40 types which may infect the genital region partea oral a faringelui . Conform unor studii affect both men and women and they may also recente, infecia cu HPV poate crete i riscul de infect the oropharynx[3,4].
Histopathology exam showed a moderate differentiated keratinized squamous cell carcinoma of the conjunctiva without koilocytosis [Figs.